Sinead Nguyen

The paper develops a method to specifically capture prostate-derived extracellular vesicles from urine, enabling transcriptomic analysis and improving specificity for prostate cancer detection.

This study compares EV transcriptomics, proteomics, and cfDNA methylation for detecting colorectal neoplasia, finding EV transcriptomics most sensitive for advanced adenomas and CRC.

This study identifies RNA biomarkers in salivary extracellular vesicles for diagnosing Sjogrens subtypes with high sensitivity and specificity.

The paper develops a targeted RNA capture method to enhance detection of long RNAs in EVs from human biofluids, revealing biofluid-specific transcriptomes and splicing patterns.

This study shows mechanical compression induces tissue-like multicellularity in haloarchaea, forming structures with distinct molecular and mechanical features similar to eukaryotic tissues.

This study shows that SARS-CoV-2 Nsp14 alters the host transcriptome, splicing, and circRNA levels, with IMPDH2 mediating these effects through GTP regulation.