The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia
Rebecca E. Ling, Alia M. N. Welsh, Lucy Hamer, Thomas Jackson, Emily Neil, Natalina Elliott, Joe W. Cross, Arundhati S Wuppalapati, Alastair Smith, Catherine Chahrour, Okan Sevim, David A. Palmer, Yavor K. Bozhilov, Elizabeth Brown, Leonid Olender, , Anindita Roy
This study identifies LIN28B as essential for fetal B-lymphopoiesis and KMT2A::AFF1 infant leukemia initiation, showing its role in promoting proliferation and leukemogenesis.
Blood · May 29, 2026Peer-reviewedCancer Biology