Author

Okan Sevim

University of SussexORCID 0000-0002-3348-3913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

David A. PalmeriD· 3 shared Rhys G. MorganiD· 3 shared Aaron GoffiD· 2 shared Anindita RoyiD· 2 shared H. ParkiD· 2 shared Megan WagstaffiD· 2 shared Rebecca E. LingiD· 2 shared Sarah Faith NewburyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

David A. PalmerORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 19, 2026

LIN28B is a post-transcriptional regulator of Wnt signalling in myeloid leukemia cells and dual targeting promotes cytotoxicity

Okan Sevim, Megan Wagstaff, Rebecca E. Ling…·Gareth Morgan

This study identifies LIN28B as a post-transcriptional regulator of Wnt/{beta}-catenin signalling in myeloid leukemia cells and shows that dual targeting enhances cytotoxicity.

DOI 10.64898/2026.01.25.698240

humanscRNA-seq

Cancer BiologyBloodPeer-reviewedMay 29, 2026

The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia

Rebecca E. Ling, Alia M. N. Welsh, Lucy Hamer…·Anindita Roy

This study identifies LIN28B as essential for fetal B-lymphopoiesis and KMT2A::AFF1 infant leukemia initiation, showing its role in promoting proliferation and leukemogenesis.

3 citationstop 2%

humanbulk RNA-seq

Cancer BiologybioRxivPreprintDec 15, 2025

TOE1 influences canonical Wnt signalling in myeloid leukaemia cells through LEF-1 modulation and regulates the proliferation of haematopoietic cells through PAK2.

H. Park, O Sevim, M Wagstaff…·RG Morgan

This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.

1 citation

humanbulk RNA-seq