Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to virus escape
JOHN CLARKE, Luke M. Jones, Imogen Buckle, Parul Sharma, Emily Park, Anja Kipar, Adam Kirby, Daniele F. Mega, Siva Ramadurai, Aparajita Karmakar, Katy A. S. Cornish, Leah McCaffrey, Hannah Campaigne, Lauren E.-A. Eyssen, William James, , Raymond J. Owens
This study identifies two potent nanobodies targeting the conserved S2 region of SARS-CoV-2 spike protein that resist viral escape and reduce viral load in a hamster model.
bioRxiv · Jan 8, 2026 · PreprintMolecular Biology