Author

JOHN CLARKE

Rosalind Franklin InstituteORCID 0000-0001-7891-7626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electronic health records· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adam KirbyiD· 1 shared Anja KipariD· 1 shared Antoni G. WrobeliD· 1 shared Antonio Di MaioiD· 1 shared Aparajita Karmakar· 1 shared Daniele F. MegaiD· 1 shared Donald J. BentoniD· 1 shared Emily Park· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Adam KirbyORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 1, 2026

Mechanism of spike opening in a mammalian gammacoronavirus

John D. Clarke, Michalina Grabias, Antonio Di Maio…·Antoni G. Wrobel

This study reports the structures of a mammalian gamma-CoV spike in closed and open conformations, revealing conserved mechanisms of spike dynamics and lipid binding's role in stabilizing the closed state.

DOI 10.64898/2026.09.30.755498

mouseelectronic health records

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Molecular BiologybioRxivPreprintJan 8, 2026

Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to virus escape

JOHN CLARKE, Luke M. Jones, Imogen Buckle…·Raymond J. Owens

This study identifies two potent nanobodies targeting the conserved S2 region of SARS-CoV-2 spike protein that resist viral escape and reduce viral load in a hamster model.

1 citation

experimental assay

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