Parul Sharma

The pharmacokinetics, bio-distribution and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in the golden Syrian hamster COVID-19 model

This study evaluates the pharmacokinetics, biodistribution, and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in golden Syrian hamsters, showing that intranasal administration provides effective respiratory exposure and therapeutic benefit.

The biodistribution and effect of post-exposure neutralising monoclonal antibody treatment in a mouse model of SARS-CoV-2 infection with viral spread to the brain

This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.

Helminth coinfection facilitates gammaherpesvirus infection in the wood mouse Apodemus sylvaticus

This study shows helminth infection increases susceptibility to gammaherpesvirus in wood mice, with anthelmintic treatment reducing viral infection and improved nutrition mitigating this effect.

Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to virus escape

This study identifies two potent nanobodies targeting the conserved S2 region of SARS-CoV-2 spike protein that resist viral escape and reduce viral load in a hamster model.

Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings

This paper evaluates the efficacy of multimeric bicyclic peptides as antiviral agents in preclinical SARS-CoV-2 models, showing significant reduction in viral burden across multiple therapeutic settings.

The K18-hACE2 mouse model of SARS-CoV-2 infection to illustrate the role and response of the vasculature in neurotropic viral infection

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts broadly with sarbecoviruses.

This study identifies two bovine-derived monoclonal antibodies with ultra-long CDRH3 domains that broadly neutralize SARS-CoV-2 and sarbecoviruses.

Phlorotannin rich Ascophyllum nodosum seaweed extract inhibits influenza infection

This study shows that an Ascophyllum nodosum extract inhibits influenza virus infection by targeting virions and neuraminidase activity, reducing viral load in mice.

Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression

This study shows that hypoxia inducible factors (HIFs) suppress RSV infection by reducing nucleolin expression and inhibiting viral replication and inflammation.