Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer's Disease
Joseph P. Voth, Javier A. Ramos Benitez, Angela M. Wilson, Scott R. Kennedy, Mamatha Damodarasamy, Amanda Kirkland, Jeremy A. Miller, Caitlin S. Latimer, Emily Ragaglia, Amber Nolan, Daniel D. Child, Lisa M. Keene, Cindy Reichel, Brendan F. Kohrn, Larry S. Sherman, , C. Dirk Keene
The paper uses single-nucleus RNA sequencing and spatial transcriptomics to compare oligodendrocyte functions in gray and white matter across aging and Alzheimer's Disease.
bioRxiv · Sep 3, 2026 · PreprintNeuroscience