Caitlin S. Latimer

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to compare oligodendrocyte functions in gray and white matter across aging and Alzheimer's Disease.

This study uses single-nucleus RNA-seq, ATAC-seq, and Multiome to analyze Alzheimer's disease across multiple brain regions, revealing shared and region-specific cellular vulnerabilities.

This paper performs a large-scale GWAS meta-analysis of neuropathologic lesions in Alzheimer's disease and related dementias, identifying both known and novel genetic associations.

The paper introduces a pipeline to create 3D spatial atlases for brain tissue samples, enabling standardized referencing and integration across biorepositories and neuroimaging data.

QNPtoVox maps 2D quantitative neuropathology data to 3D MNI voxel space for spatial standardization and integration with neuroimaging tools.

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

The paper determines the structures of tau filaments in individuals with MAPT mutations V337M and R406W using cryo-EM, finding the Alzheimer fold in all cases and a new triple filament assembly.

This study creates an integrated multimodal cell atlas of Alzheimer's disease by analyzing single nuclei transcriptomes, epigenomes, and spatial coordinates across AD stages.

This study shows that AQP4 mis-localization impairs glymphatic clearance of α-synuclein and promotes its aggregation and spread in neurodegenerative diseases.

This study uses MD-MRI to map cortical astrogliosis and distinguishes cognitive resilience from dementia in Alzheimer's disease despite significant neuropathology.

The paper identifies a pathogenic SORL1 variant, p.R953C, associated with Alzheimer's Disease and shows it impairs protein maturation and endosomal sorting.

The paper develops open-source tools for 3D analysis of brain dissection photographs and surface scans, achieving accurate reconstructions and segmentations comparable to MRI.

The paper analyzes synaptic molecular changes in Alzheimer's disease and related conditions using mass cytometry and imaging, identifying disease-specific molecular differences.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.