Author

Emma McSpadden

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Organism:mouse· 2 Research Focus:database / resource· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anitha SundararajaniD· 2 shared Ashley M. SidebottomiD· 2 shared Che Woodson· 2 shared Eric G. PameriD· 2 shared Huaiying LiniD· 2 shared Qiwen DongiD· 2 shared Sophie S SoniD· 2 shared Aimee SheniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

Anitha SundararajanORCID

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3 papers

Recent·Most cited

Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance

Cody G. Cole, Zhenrun Jerry Zhang, Shravan R. Dommaraju, Qiwen Dong, Rosemary L. Pope, Sophie S Son, Emma McSpadden, Che Woodson, Huaiying Lin, Nicholas P. Dylla, Ashley M. Sidebottom, Anitha Sundararajan, Douglas A. Mitchell, Eric G. Pamer

This study shows lantibiotic-producing bacteria reduce microbiome resilience and increase susceptibility to infections after antibiotic treatment.

Cell Host & Microbe · Dec 1, 2025Peer-reviewedMicrobiology

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

Qiwen Dong, Stephen Harper, Emma McSpadden, Sophie S Son, Marie-Maude Allen, Huaiying Lin, Rita C. Smith, Carolyn K. Metcalfe, Victoria Burgo, Che Woodson, Anitha Sundararajan, Amber R. Rose, Mary McMillin, David Moran, Jessica Little, , Eric G. Pamer

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

Cell Host & Microbe · Nov 27, 2024Peer-reviewedMicrobiology

Statistical design of a synthetic microbiome that suppresses diverse gut pathogens

Rita A. Oliveira, Emma McSpadden, Bipul Pandey, Kiseok Keith Lee, Mahmoud Yousef, Robert Yuzen Chen, Conrad Triebold, Fidel Haro, Valeryia Aksianiuk, Riya Patel, Kaavya Shriram, Ramanujam Ramaswamy, Seppe Kuehn, Arjun S. Raman

The paper designs a synthetic microbiome that suppresses gut pathogens using a statistical approach, showing it effectively clears Kp-MH258 in multiple environments.

bioRxiv · Feb 28, 2024 · PreprintSynthetic Biology