Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT Aggregation
Melissa A Solem, Ross J. Pelzel, Nicholas B Rozema, Taylor G. Brown, Emma Reid, Rachel H. Mansky, Rocío Gómez‐Pastor
This study compares mHTT aggregation and neuropathology in the striatum and hippocampus of two HD mouse models, finding enhanced spare capacity in the hippocampus despite similar mHTT levels.
bioRxiv · Oct 14, 2024 · PreprintNeuroscience