Author

Taylor G. Brown

University of MinnesotaORCID 0000-0001-9817-2094Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Rocío Gómez‐PastoriD· 3 shared Nicole ZarateiD· 2 shared Rachel H. ManskyiD· 2 shared Alfonso AraqueiD· 1 shared Angel WhiteiD· 1 shared Carmen NanclaresiD· 1 shared Cristina Tomás‐ZapicoiD· 1 shared Dahyun YuiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Rocío Gómez‐PastorORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 14, 2024

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT Aggregation

Melissa A Solem, Ross J. Pelzel, Nicholas B Rozema…·Rocío Gómez‐Pastor

This study compares mHTT aggregation and neuropathology in the striatum and hippocampus of two HD mouse models, finding enhanced spare capacity in the hippocampus despite similar mHTT levels.

DOI 10.1101/2024.10.14.618355

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedJun 3, 2022

CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington's disease

Dahyun Yu, Nicole Zarate, Angel White…·Rocío Gómez‐Pastor

This study shows that reducing CK2 in HD mice improves neuroinflammation, HTT aggregation, and motor deficits by reducing synucleinopathy.

29 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 29, 2021

Striatal compartmentalization and clustering of different subtypes of astrocytes is altered in the zQ175 Huntington's disease mouse model

Taylor G. Brown, Mackenzie N. Thayer, Nicole Zarate, Rocío Gómez‐Pastor

The paper examines changes in astrocyte subtypes in HD mouse models, finding increased GFAP+ astrocyte density and clustering in specific striatal regions.

DOI 10.1101/2021.11.29.470488

mouseprotein structure

𝕏 PostBluesky