Author

Ross J. Pelzel

University of MinnesotaORCID 0009-0002-2027-7018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Nicholas B RozemaiD· 2 shared Rocío Gómez‐PastoriD· 2 shared Emma Reid· 1 shared Melissa A Solem· 1 shared Melissa A. Solem· 1 shared Miaya Herbst· 1 shared Rachel H. ManskyiD· 1 shared Taylor G. BrowniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Nicholas B RozemaORCID

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2 papers

Recent·Most cited

NeuroscienceNeurotherapeuticsPeer-reviewedJan 1, 2026

Silmitasertib, an FDA-designated orphan CK2 Inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model

Ross J. Pelzel, Miaya Herbst, Nicholas B Rozema…·Rocío Gómez‐Pastor

This study shows that Silmitasertib reduces mHtt aggregation and improves motor function in Huntington's disease mice.

1 citation

mouseexperimental assay

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NeurosciencebioRxivPreprintOct 14, 2024

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT Aggregation

Melissa A Solem, Ross J. Pelzel, Nicholas B Rozema…·Rocío Gómez‐Pastor

This study compares mHTT aggregation and neuropathology in the striatum and hippocampus of two HD mouse models, finding enhanced spare capacity in the hippocampus despite similar mHTT levels.

DOI 10.1101/2024.10.14.618355

mouseexperimental assay

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