Rocío Gómez‐Pastor

This study identifies HSF1's role in regulating thalamostriatal synapses and cognitive flexibility by controlling transcriptional programs and actin dynamics.

This study shows that Silmitasertib reduces mHtt aggregation and improves motor function in Huntington's disease mice.

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

This study identifies CK2 as a regulator of tauopathy by modulating tau phosphorylation, neuroinflammation, and synaptic dysfunction in mice.

This study compares mHTT aggregation and neuropathology in the striatum and hippocampus of two HD mouse models, finding enhanced spare capacity in the hippocampus despite similar mHTT levels.

The paper identifies two CK2α' selective inhibitors from a compound library using a kinase assay, offering potential for treating Huntington's disease.

This study shows that reducing CK2 in HD mice improves neuroinflammation, HTT aggregation, and motor deficits by reducing synucleinopathy.

The paper examines changes in astrocyte subtypes in HD mouse models, finding increased GFAP+ astrocyte density and clustering in specific striatal regions.

This study links in vivo 1H-MRS neurochemical changes to specific synaptic pathway alterations in a Huntington's disease mouse model.