Author

Nicholas B Rozema

University of MinnesotaORCID 0000-0002-7730-6097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Rocío Gómez‐PastoriD· 4 shared Persephone GuiD· 2 shared Rachel H. ManskyiD· 2 shared Ross J. PelzeliD· 2 shared Ying ZhangiD· 2 shared Aishwarya BhowmikiD· 1 shared Alfonso AraqueiD· 1 shared Amal Fickak· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersNeuroscience

Rocío Gómez‐PastorORCID

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Author profile →

4 papers

Recent·Most cited

HSF1 controls transcriptional programs that establish thalamostriatal shaft synaptic architecture and preserve cognitive flexibility

Nicholas B Rozema, Nicole Zarate, Rachel H. Mansky, Persephone Gu, Kinsey Gerlach, Aishwarya Bhowmik, James H. Cho, Ying Zhang, Arif Hamid, Steven M. Graves, Rocío Gómez‐Pastor

This study identifies HSF1's role in regulating thalamostriatal synapses and cognitive flexibility by controlling transcriptional programs and actin dynamics.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

Silmitasertib, an FDA-designated orphan CK2 Inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model

Ross J. Pelzel, Miaya Herbst, Nicholas B Rozema, Melissa A. Solem, Rocío Gómez‐Pastor

This study shows that Silmitasertib reduces mHtt aggregation and improves motor function in Huntington's disease mice.

Neurotherapeutics · Jan 1, 2026Peer-reviewedNeuroscience

Protein kinase CK2 alpha prime as a dual modulator of neuroimmune signaling and synaptic dysfunction in Tauopathy

Angel White, Peter Gavrilyuk, Persephone Gu, Rafael Falcon Moya, Reid Thurston, Amal Fickak, Nicholas B Rozema, Prarthana Keshavaram, Scott Vermilyea, Riley Schlichte, Joyce P. Meints, Ying Zhang, Alfonso Araque, Michael K. Lee, Rocío Gómez‐Pastor

This study identifies CK2 as a regulator of tauopathy by modulating tau phosphorylation, neuroinflammation, and synaptic dysfunction in mice.

bioRxiv · Jun 24, 2025 · PreprintNeuroscience

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT Aggregation

Melissa A Solem, Ross J. Pelzel, Nicholas B Rozema, Taylor G. Brown, Emma Reid, Rachel H. Mansky, Rocío Gómez‐Pastor

This study compares mHTT aggregation and neuropathology in the striatum and hippocampus of two HD mouse models, finding enhanced spare capacity in the hippocampus despite similar mHTT levels.

bioRxiv · Oct 14, 2024 · PreprintNeuroscience