Author

Emma S Winkler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adam L Bailey· 1 shared Annette Robichaud· 1 shared Brittany Smith· 1 shared Broc T McCune· 1 shared Broc T. McCune· 1 shared Daved H. FremontiD· 1 shared Ian B. Harvey· 1 shared James Brett CaseiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Adam L Bailey

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2 papers

Recent·Most cited

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis

James Brett Case, Paul Rothlauf, Rita E. Chen, Natasha Kafai, Julie M. Fox, Swathi Shrihari, Broc T. McCune, Ian B. Harvey, Brittany Smith, Shamus Keeler, Louis-Marie Bloyet, Emma S Winkler, Michael J. Holtzman, Daved H. Fremont, Sean P. J. Whelan, Michael S. Diamond

This study develops a replication-competent VSV-based vaccine against SARS-CoV-2 that elicits neutralizing antibodies and protects mice from viral infection and lung inflammation.

Cell Host & Microbe · Sep 1, 2020Peer-reviewedImmunology

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

Emma S Winkler, Adam L Bailey, Natasha M Kafai, Sharmila Nair, Broc T McCune, Jinsheng Yu, Julie M Fox, Rita E Chen, James T Earnest, Shamus P Keeler, Jon H Ritter, Liang-I Kang, Sarah Dort, Annette Robichaud, Richard Head, , Michael S Diamond

This study shows that SARS-CoV-2 infection in K18-hACE2 mice causes severe lung inflammation, immune cell infiltration, and respiratory dysfunction similar to human COVID-19.

bioRxiv · Jul 9, 2020 · PreprintImmunology