Daved H. Fremont

TMEM106B mediates ACE2-independent replication of the SARS-CoV-2 S-E484D variant in airway-derived cell models

This study identifies TMEM106B as an alternative receptor for SARS-CoV-2 S-E484D variant entry, independent of ACE2, in airway-derived cell models.

CD164 is an endolysosomal host factor for entry of Clade A New World Arenaviruses

The paper identifies CD164 as an endolysosomal receptor for clade A New World arenaviruses, expanding the receptor switching paradigm observed in Old World arenaviruses.

Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins

This study identifies amino-acid mutations in CHIKV envelope proteins that affect entry in human and mosquito cells, revealing species-specific determinants of viral tropism.

The neonatal Fc receptor and DPP4 are human astrovirus receptors

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis

This study develops a replication-competent VSV-based vaccine against SARS-CoV-2 that elicits neutralizing antibodies and protects mice from viral infection and lung inflammation.