James Brett Case

A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variants

This paper describes a miniprotein inhibitor that neutralizes multiple SARS-CoV-2 variants and protects mice against them when administered post-exposure.

Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex

The paper shows that short 5' UTRs in viral mRNAs are recognized by the IFIT2-IFIT3 complex, leading to translation inhibition and antiviral activity.

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

This paper develops tetravalent SARS-CoV-2 neutralizing antibodies that are more potent and resistant to escape mutations than bivalent versions.

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

The paper designs picomolar SARS-CoV-2 miniprotein inhibitors using computational methods and experimental validation, showing high potency and structural similarity to computational models.

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis

This study develops a replication-competent VSV-based vaccine against SARS-CoV-2 that elicits neutralizing antibodies and protects mice from viral infection and lung inflammation.