Metastatic Osteosarcoma is Characterized by Loss of Osteoblastic Lineage Fidelity
Yutaro Tanaka, James J. Morrow, Salvador Casaní-Galdón, Erica Maria Pimenta, Jiayi Li, Byron Butaney, Chadi A. El Farran, Julie Karam, Joshua P. D’Antonio, Kevin Bi, Laura Valderrábano, Sabrina Yvonne Camp, Yun Jee Kang, Shreya Johri, Lester Heredia Gopar, , Riaz Gillani
This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.
bioRxiv · Jun 12, 2026 · PreprintCancer Biology