Structural insights into glycine reuptake inhibition
Azadeh Shahsavar, Peter Stohler, Gleb P. Bourenkov, Iwan Zimmermann, Martin Siegrist, Wolfgang Guba, Emmanuel Pinard, Steffen Sinning, Markus A. Seeger, Thomas R. Schneider, Roger J. P. Dawson, Poul Nissen
The paper determines the structure of GlyT1 bound to an inhibitor, revealing its mechanism of non-competitive inhibition and informing drug design.
Nature · Mar 3, 2021Peer-reviewedNeuroscience