Azadeh Shahsavar

This study presents cryo-EM structures of human GAT3 bound to inhibitor, substrate GABA, or in substrate-free state, revealing molecular mechanisms of inhibition and substrate recognition.

This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.

The paper determines the structure of GlyT1 bound to an inhibitor, revealing its mechanism of non-competitive inhibition and informing drug design.