The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies.
Marta Krawczyk, Narcís Fernández‐Fuentes, Klaudyna Fidyt, Tomasz Winiarski, Monika Pępek, Agnieszka Graczyk‐Jarzynka, Jacinta Davis, Pablo Bousquets‐Muñoz, Xosé S. Puente, Pablo R. Menéndez, Emmanuelle Benard, Sébastien Wälchli, Andrei Thomas‐Tikhonenko, Magdalena Winiarska
This study identifies that the costimulatory domain of CD19-CAR-T cells influences resistance development in B-cell malignancies by affecting CD19 loss and antigen escape.
bioRxiv · Feb 28, 2025 · PreprintImmunology