Pablo R. Menéndez

TET2-driven activation of AGO2 links epigenetic remodeling to myeloid commitment and leukemia

The paper identifies a TET2-AGO2 regulatory axis that links epigenetic remodeling to myeloid commitment and leukemia progression.

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.

CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia

This paper develops and validates a dual-targeting CAR-T cell therapy for T-ALL that targets CCR9 and CD1a, showing improved efficacy and safety compared to single-targeting approaches.

The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies.

This study identifies that the costimulatory domain of CD19-CAR-T cells influences resistance development in B-cell malignancies by affecting CD19 loss and antigen escape.

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution

The paper introduces liCHi-C, a low-input Hi-C method, to map promoter-enhancer interactions in clinical samples and identify disease-relevant regulatory elements and structural variants.

Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2.

The paper identifies IGFBP2 as a key factor secreted by arterial cells that enhances hematopoietic progenitor development in vitro.