Non-integrating direct reprogramming generates therapeutic endothelial cells with sustained vascular regeneration capacity enhanced by nanomatrix delivery
Sangho Lee, Dandan Chen, Yoshiaki Tanaka, Seongho Bae, Han Jacob Li, Er Yearn Jang, Eric Chan, In‐Hyun Park, Ho‐Wook Jun, Changwon Park, Young‐sup Yoon
This study generates therapeutic endothelial cells from fibroblasts using non-integrating adenoviral ETV2 and enhances their long-term engraftment with nanomatrix delivery, showing sustained vascular regeneration in a mouse model.
bioRxiv · Sep 24, 2025 · PreprintCell Biology