Eric Chan

Microscale Characterization of Undecalcified Bone Tissue Using Correlative Atomic Force Microscopy and Histology

This study develops a method combining AFM and histology to analyze undecalcified bone tissue, revealing age-related changes in structure and stiffness in mice.

Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD

Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.

Non-integrating direct reprogramming generates therapeutic endothelial cells with sustained vascular regeneration capacity enhanced by nanomatrix delivery

This study generates therapeutic endothelial cells from fibroblasts using non-integrating adenoviral ETV2 and enhances their long-term engraftment with nanomatrix delivery, showing sustained vascular regeneration in a mouse model.

Intracellular acidification by bacteria-derived valeric acid is a mechanism of trans-kingdom ecology against Candida parapsilosis colonization

The paper uses machine learning to identify valeric acid as a bacterial metabolite that inhibits Candida parapsilosis growth through intracellular acidification, reducing fungal colonization in mice.

Early-life microbiota disruption by antibiotics elicits fitness trade-offs that differ by sex

This study shows that early-life antibiotic exposure causes sex-specific fitness trade-offs in mice, with males showing reduced lean mass and increased adiposity, while females show no metabolic changes but worse fitness under caloric restriction.