Readout of histone methylation by Trim24 locally restricts chromatin opening by p53
Luke Isbel, Murat Iskar, Sevi Durdu, Joscha Weiss, Ralph Stefan Grand, Eric Hietter-Pfeiffer, Zuzanna Kozicka, Alicia K. Michael, Lukas Burger, Nicolas H. Thomä, Dirk Schübeler
This study shows that Trim24 restricts p53's ability to open chromatin by binding to closed chromatin regions and interacting with unmethylated histone H3 lysine 4.
Nature Structural & Molecular Biology · Jun 29, 2023Peer-reviewedGenomics