Author

Ralph Stefan Grand

Heidelberg UniversityORCID 0000-0001-9193-5239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ada L. OlinsiD· 1 shared Alicia K. MichaeliD· 1 shared Dirk SchübeleriD· 1 shared Donald E. OlinsiD· 1 shared Elsie C. JacobsoniD· 1 shared Eric Hietter-Pfeiffer· 1 shared Faustus Tuschmann· 1 shared Izlem Su AkaniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperGenomics

Ada L. OlinsORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintApr 30, 2026

Essential genes are dominantly activated by single transcription factors

Martina Capriati, Sylke Nestmann, Izlem Su Akan…·Ralph Stefan Grand

The paper shows that single transcription factors dominantly activate essential genes through regulatory dominance rather than cooperation in murine stem cells.

1 citation

mouseChIP-seq

𝕏 PostBluesky

GenomicsNature Structural & Molecular BiologyPeer-reviewedJun 29, 2023

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53

Luke Isbel, Murat Iskar, Sevi Durdu…·Dirk Schübeler

This study shows that Trim24 restricts p53's ability to open chromatin by binding to closed chromatin regions and interacting with unmethylated histone H3 lysine 4.

40 citations

humanChIP-seq

𝕏 PostBluesky

GenomicsGenomicsPeer-reviewedMay 13, 2019

Hi-C detects novel structural variants in HL-60 and HL-60/S4 cell lines

Elsie C. Jacobson, Ralph Stefan Grand, Jo Kate Perry…·Justin Martin O'Sullivan

The paper uses Hi-C and RNA-seq to identify and compare structural variants in HL-60 and HL-60/S4 cell lines, finding novel SVs and differences in their stability.

23 citations

humanHi-C

𝕏 PostBluesky