Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting
Elisa Ruffo, Adam Butchy, Yaniv Tivon, Victor So, Michael Kvorjak, Avani Bharat Parikh, Eric L. Adams, Nataša Miškov-Živanov, Olivera J. Finn, Alexander Deiters, Jason J. Lohmueller
This paper introduces SNAP-CAR and SNAP-synNotch receptors that can be post-translationally targeted by BG-conjugated antibodies to activate T cell signaling or gene programs in an antigen-specific manner.
Nature Communications · May 9, 2023Peer-reviewedSynthetic Biology