Alexander Deiters

The paper introduces CAGE-TRX, a method for time-resolved crystallography that uses photocaged amino acids to control enzyme activity and capture reaction intermediates.

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

This paper demonstrates a method to enhance protein degradation by recruiting E3 ligases to specific protein sites, showing improved degradation of target proteins and informing PROTAC development.

This paper uses visible light to control specific protein reactions in mammalian cells, revealing early stages of cell adhesion and mechanotransduction.

This paper introduces OFF-switch adaptors to conditionally control universal CAR T cells using small molecules or light, enabling precise targeting and enhanced safety.

This paper introduces SNAP-CAR and SNAP-synNotch receptors that can be post-translationally targeted by BG-conjugated antibodies to activate T cell signaling or gene programs in an antigen-specific manner.

This paper demonstrates the use of PhoCl, a photocleavable fluorescent protein, to achieve optical control over protein cleavage in zebrafish embryos, enabling light-triggered protein translocation and apoptosis.

The paper introduces a photochemical NOT gate for DNA computing that uses photocaging groups to enable temporal control, allowing for the design of NAND and NOR gates and demonstrating their use in multi-layer circuits.

This paper introduces a method to control CRISPR/Cas9 activity using light-activated guide RNAs, enabling precise spatiotemporal gene editing in cells and zebrafish embryos.