Jason J. Lohmueller

CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in microwell arrays

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.

Conditional control of universal CAR T cells by cleavable OFF-switch adaptors.

This paper introduces OFF-switch adaptors to conditionally control universal CAR T cells using small molecules or light, enabling precise targeting and enhanced safety.

Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting

This paper introduces SNAP-CAR and SNAP-synNotch receptors that can be post-translationally targeted by BG-conjugated antibodies to activate T cell signaling or gene programs in an antigen-specific manner.