Elisa Ruffo

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.

This paper introduces OFF-switch adaptors to conditionally control universal CAR T cells using small molecules or light, enabling precise targeting and enhanced safety.

This paper introduces SNAP-CAR and SNAP-synNotch receptors that can be post-translationally targeted by BG-conjugated antibodies to activate T cell signaling or gene programs in an antigen-specific manner.