Author

Eric S Lander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:GWAS / association mapping· 1 Research Focus:protein design· 1

Frequent Co-Authors

Pradeep NatarajaniD· 2 shared Sekar KathiresaniD· 2 shared Andres MetspaluiD· 1 shared Anis Memon· 1 shared Anne H ODonnell-Luria· 1 shared Asif Rasheed· 1 shared Atif Imran· 1 shared Aviv RegeviD· 1 shared

Activity by Year

2015-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Pradeep NatarajanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

Michael Guo, Satish K Nandakumar, Jacob C Ulirsch, Seyedeh Maryam Zekavat, Jason D Buenrostro, Pradeep Natarajan, Rany Salem, Roberto Chiarle, Mario Mitt, Mart Kals, Kalle Parn, Krista Fischer, Lili Milani, Reedik Magi, Priit Palta, , Vijay G Sankaran

This study uses genome sequencing and epigenomic data to identify genetic variants influencing blood cell traits and uncover regulatory mechanisms in hematopoiesis.

Proceedings of the National Academy of Sciences · Dec 28, 2016Peer-reviewedGenetics

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Omar O Abudayyeh, Jonathan S Gootenberg, Silvana Konermann, Julia Joung, Ian M Slaymaker, David BT Cox, Sergey Shmakov, Kira S Makarova, Ekaterina Semenova, Leonid Minakhin, Konstantin Severinov, Aviv Regev, Eric S Lander, Eugene V Koonin, Feng Zhang

This study characterizes C2c2, a CRISPR-Cas effector that uses an RNA guide to target and cleave RNA, showing its potential as a programmable RNA-targeting tool.

Science · Aug 5, 2016Peer-reviewedMolecular Biology

Human knockouts in a cohort with a high rate of consanguinity

Danesh Saleheen, Pradeep Natarajan, Wei Zhao, Asif Rasheed, Sumeet Khetarpal, Hong-Hee Won, Konrad J Karczewski, Anne H ODonnell-Luria, Kaitlin E Samocha, Namrata Gupta, Mozzam Zaidi, Maria Samuel, Atif Imran, Shahid Abbas, Faisal Majeed, , Sekar Kathiresan

The paper identifies homozygous null mutations in 961 genes in a consanguineous Pakistani cohort and reports their phenotypic consequences.

bioRxiv · Nov 12, 2015Genomics