Julia Joung

The paper identifies a cell-state-dependent pathway for degrading ER-retained 60S ribosomal subunits through UFMylation loss and the action of TLSD1.

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

This paper develops a platform to model and manipulate human microglial states in vitro using single-cell RNA sequencing and genetic tools, identifying disease-associated transcriptional signatures.

This paper describes a protocol for genome-scale CRISPR-Cas9 knockout and transcriptional activation screening, including library design, validation strategies, and timing estimates.

This paper uses a CRISPR screen to identify noncoding genomic elements that influence drug resistance in melanoma cells.

This study characterizes C2c2, a CRISPR-Cas effector that uses an RNA guide to target and cleave RNA, showing its potential as a programmable RNA-targeting tool.