Sergey Shmakov

A Unique Type V CRISPR-Cas System Encoded by a Group of Thermus Viruses

The paper identifies and characterizes a novel type V CRISPR-Cas system, Cas12r-CRISPR, encoded by Lalka phages in Thermus bacteria, showing its role in targeting mobile genetic elements.

Widespread CRISPR repeat-like RNA regulatory elements in CRISPR-Cas systems

The paper identifies CRISPR repeat-like RNA elements in CRISPR-Cas systems that function as regulatory guides, showing their prevalence in type I and V-A systems.

Cargo genes of Tn7-like transposons comprise an enormous diversity of defense systems, mobile genetic elements and antibiotic resistance genes

The paper identifies cargo genes of Tn7-like transposons, revealing their role in transferring diverse genes including MGEs, defense systems, and antibiotic resistance genes.

CRISPRIdentify: Identification of CRISPR arrays using machine learning approach

CRISPRIdentify uses machine learning to detect CRISPR arrays with reduced false positives and provides certainty scores for identified regions.

Towards comprehensive characterization of CRISPR-linked genes

The paper develops a computational method to identify genes likely functionally linked to CRISPR-Cas systems, identifying 80 previously undetected candidate genes, many associated with membrane and signal transduction.

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

This study characterizes C2c2, a CRISPR-Cas effector that uses an RNA guide to target and cleave RNA, showing its potential as a programmable RNA-targeting tool.