Architecture and Function of Holocentric CENP-A-Independent Kinetochores
Christine Yu, Sundar Ram Sankaranarayanan, Gaetan Cornilleau, Anna C. Howes, Caleigh M. Azumaya, Eric S. Day, Inna Zilberleyb, Bobby Brillantes, Tommy K. Cheung, Léonie Dec, Damarys Loew, Phong Thanh Tran, Christopher M. Rose, Ines Anna Drinnenberg, Claudio Ciferri, Stanislau Yatskevich
The paper determines the cryo-EM structure of the holocentric CCAN from Bombyx mori, revealing a self-contained dimer that forms a point-centromere-like architecture and incorporates novel Centromeric Subunit proteins.
Science Advances · Jun 19, 2026Peer-reviewedCell Biology