The mechanism of cysteine sensing by LRRC58
Emma C. Fink, Hilina B. Woldemichael, Nikhit Kambdur, Muneeb A. Sharif, Talya S. Levitz, Bindu Srinivasu, Marie Blickling, Bingsen Zhang, Jiuchun Zhang, Yaoyu Wang, Filipe Cabreiro, Thomas E. Wales, Eric S. Fischer, Edward T. Chouchani
This study identifies how LRRC58 senses cysteine through structural changes that regulate CDO1 binding and cysteine homeostasis.
bioRxiv · Nov 4, 2026 · PreprintCell Biology