Edward T. Chouchani

The mechanism of cysteine sensing by LRRC58

This study identifies how LRRC58 senses cysteine through structural changes that regulate CDO1 binding and cysteine homeostasis.

Quantitative imaging of native tissue architecture combined with deep multi-omics reveals the spatial biology of kidney aging

This paper introduces NORIGAMI, a multi-omics pipeline that combines imaging and deep learning to analyze kidney aging, revealing age-related structural and molecular changes.

Redox activation of ATG5 licenses autophagy upon nutrient restriction

The paper identifies redox regulation of ATG5's Cys19 as critical for autophagy initiation under nutrient restriction in human cells and mice.

A quantitative redox proteome of the human muscle response to exercise

Site-resolved redox proteomics of human muscle after three exercise types shows modality-specific cysteine oxidation, and a p62 Cys113 switch tied to autophagy in myotubes and mitochondrial remodeling in mice.

Multi-omic characterization of axolotl perilymph-cerebrospinal fluid reveals shifts in composition during limb regeneration

This study characterizes axolotl perilymph-cerebrospinal fluid (P-CSF) during limb regeneration, identifying proteomic and metabolomic changes associated with amputation.

Oxidized protein states define metastatic fitness in lung cancer

The paper identifies oxidative protein states as drivers of metastatic fitness in lung cancer by linking ROS-regulated protein modifications to mitochondrial function and metastasis.

A druggable redox switch on SHP1 controls macrophage inflammation

This paper identifies a druggable redox switch on SHP1 that controls macrophage inflammation by developing a covalent agonist targeting a specific cysteine residue.

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

This study identifies mitochondrial complex III-derived ROS as a key driver of immunometabolic changes in astrocytes that contribute to dementia pathology.

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense

The paper identifies Acb4, a viral protein that inhibits bacterial anti-phage defense by sequestering nucleotide signals.

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.