Jiuchun Zhang

This study identifies how LRRC58 senses cysteine through structural changes that regulate CDO1 binding and cysteine homeostasis.

The paper identifies redox regulation of ATG5's Cys19 as critical for autophagy initiation under nutrient restriction in human cells and mice.

Site-resolved redox proteomics of human muscle after three exercise types shows modality-specific cysteine oxidation, and a p62 Cys113 switch tied to autophagy in myotubes and mitochondrial remodeling in mice.

This paper introduces VMAP, a method for absolute membrane voltage imaging, and demonstrates its application in measuring drug effects, bioelectric patterns, and 3D voltage maps in zebrafish embryos.

This study shows genetic compensation in ACTB mutants occurs via SRF/MRTF-A transcriptional feedback, independent of mutant mRNA expression or degradation.

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.

This paper develops Endo-IP and Lyso-IP methods to profile endolysosomal proteins in induced neurons, revealing cargo and machinery involved in neurodegenerative disease.

This study identifies REEP1 proteins as forming a novel ER-derived vesicular compartment and shows that mutations affecting their curvature-inducing activity lead to relocalization to the bulk ER.

The paper shows that ALS genes FUS, TAF15, and MATR3 regulate the MHC II antigen presentation pathway by downregulating HLA-DR and CD74 through loss of CIITA, with implications for immune system failure in ALS.

The paper identifies downregulation of the CCR1 immune pathway in SF3B1-mutated cancers and links it to potential therapeutic targets.

The paper shows the rixosome, an RNA degradation complex, associates with human PRC complexes and is required for silencing Polycomb target genes.