Eric Thorland

Varied monoamine reuptake inhibitors reduce parvalbumin expression; implications for pyramidal cell disinhibition and enhanced neuroplasticity

This study examines the effects of three monoamine reuptake inhibitors on parvalbumin expression and PNN remodeling in animal models, finding shared reductions in PV levels and increased PNN degrading effectors.

Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice

The paper identifies increased HAPLN2 levels in APOE4 mice hippocampus, linking it to extracellular matrix changes and potential Alzheimer's disease risk.