Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice
Samantha Deasy, Matthew Amontree, Zachary A. Colon, Eric Thorland, Kush Modi, Katie Hummel, Ismary Blanco, Griffin A. Greco, Kathleen A. Maguire‐Zeiss, Katherine E. Conant
The paper identifies increased HAPLN2 levels in APOE4 mice hippocampus, linking it to extracellular matrix changes and potential Alzheimer's disease risk.
bioRxiv · Nov 9, 2025 · PreprintNeuroscience