Author

Samantha Deasy

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:spatial transcriptomics· 2 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Derek G. SouthwelliD· 2 shared Diego Arroyo· 2 shared Dmitry VelmesheviD· 2 shared Elizabeth A. MatthewsiD· 2 shared Ismary BlancoiD· 2 shared Katherine E. ConantiD· 2 shared Kiran Shehnaz Kaur· 2 shared Lewei He· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Derek G. SouthwellORCID

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4 papers

Recent·Most cited

Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice

Samantha Deasy, Matthew Amontree, Zachary A. Colon, Eric Thorland, Kush Modi, Katie Hummel, Ismary Blanco, Griffin A. Greco, Kathleen A. Maguire‐Zeiss, Katherine E. Conant

The paper identifies increased HAPLN2 levels in APOE4 mice hippocampus, linking it to extracellular matrix changes and potential Alzheimer's disease risk.

bioRxiv · Nov 9, 2025 · PreprintNeuroscience

Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus

Zijian Zhang, Brooke R. D’Arcy, Lewei He, Diego Arroyo, Samantha Deasy, Elizabeth A. Matthews, Zihan Yan, Nirvika Rastogi, Walter Mancia Leon, Kiran Shehnaz Kaur, Derek G. Southwell, Z. Josh Huang, Debra L. Silver, Dmitry Velmeshev

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

bioRxiv · Nov 7, 2025 · PreprintNeuroscience

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus

Zijian Zhang, Jing Xu, Elizabeth A. Matthews, Samantha Deasy, Lewei He, Diego Arroyo, Enhui Pan, Arvin Deshmukh, Kiran Shehnaz Kaur, James O McNamara, Derek G. Southwell, Charles A. Gersbach, Ru-Rong Ji, Dmitry Velmeshev

The paper introduces CRISPR-rabies virus (CRV) to enable precise circuit-level gene modulation in neurons, demonstrating its ability to regulate synaptic transmission in the hippocampus.

bioRxiv · Nov 3, 2025 · PreprintNeuroscience

MMP-2/9 inhibition modulates sharp wave abundance, inhibitory proteoglycan sulfation, and fear memory in juvenile zebrafish: relevance to affective disorders

Ismary Blanco, Samantha Deasy, Matthew Amontree, Miranda Gabriel, Adam Caccavano, Stefano Vicini, Eric F. Glasgow, Katherine E. Conant

This study shows MMP-2/9 inhibition affects SWR abundance, fear memory, and sociability in juvenile zebrafish, with implications for affective disorders.

Molecular Psychiatry · May 2, 2025Peer-reviewedNeuroscience