Author

Zachary A. Colon

Georgetown UniversityORCID 0000-0002-0583-7374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Kathleen A. Maguire‐ZeissiD· 3 shared Alejandro Gamboa Fuentes· 1 shared Asia B Fernandez· 1 shared Chelsea B ScottiD· 1 shared Eric Thorland· 1 shared Giorgi Shautidze· 1 shared Griffin A. Greco· 1 shared Ismary BlancoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersNeuroscience

Kathleen A. Maguire‐ZeissORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sex-specific effects of exercise on motor coordination and extended basal ganglia physiology.

Valerie J. Lewitus, Lindsey A. Russ, Chelsea B Scott, Olivia M Kruszewski, Giorgi Shautidze, Zachary A. Colon, Shirley Q Zhang, Joel A Walker, Asia B Fernandez, Megan R Croom, Valeria G Aleman, Rebekah C. Evans

The paper investigates sex-specific effects of exercise on motor coordination and basal ganglia physiology in mice, finding differential impacts on neural activity and structure in males and females.

bioRxiv · Apr 24, 2026 · PreprintNeuroscience

Glial cell and perineuronal net interactions in the dorsal striatum of aged mice

Zachary A. Colon, Alejandro Gamboa Fuentes, Scott Litwiler, Kathleen A. Maguire‐Zeiss

The paper investigates age-related changes in neuroinflammatory signaling and perineuronal net homeostasis in the dorsal striatum of aged mice, identifying microglial and astrocytic contributions to phagocytic activity and PNN remodeling.

Journal of Experimental Neurology · Apr 24, 2026Peer-reviewedNeuroscience

Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice

Samantha Deasy, Matthew Amontree, Zachary A. Colon, Eric Thorland, Kush Modi, Katie Hummel, Ismary Blanco, Griffin A. Greco, Kathleen A. Maguire‐Zeiss, Katherine E. Conant

The paper identifies increased HAPLN2 levels in APOE4 mice hippocampus, linking it to extracellular matrix changes and potential Alzheimer's disease risk.

bioRxiv · Nov 9, 2025 · PreprintNeuroscience

Age-related inflammatory changes and perineuronal net dynamics: implications for neurodegenerative disorders.

Zachary A. Colon, Shannon C. Chan, Kathleen A. Maguire‐Zeiss

This study examines age-related changes in perineuronal nets and neuroinflammation in two brain regions, finding region-specific differences in PNN integrity and microglial activation.

bioRxiv · Sep 10, 2025 · PreprintNeuroscience