Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering
Mariah S. Stewart, Chathura Paththamperuma, Colleen M. McCann, Kelsey Cottingim, Huaqun Zhang, Rian DelVecchio, Ivy Peng, Erica Fennimore, Jay C. Nix, Morcos N Saeed, Kathleen George, Katherine Makaroff, Meagan Colie, Ethan Paulаkonis, Michael Fernandes de Almeida, , Jonathan Cummings Schisler
This study examines how phosphorylation at HSP70 T636 affects its binding to CHIP, showing reduced affinity and altered interactions with other co-chaperones, with implications for disease.
bioRxiv · Feb 17, 2025 · PreprintBiochemistry