Author

Meagan Colie

University of North Carolina at Chapel HillORCID 0000-0003-2897-3851Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Adeleye James AfolayaniD· 1 shared Alexandra Barnett· 1 shared Chathura PaththamperumaiD· 1 shared Colleen M. McCanniD· 1 shared Corina Damian· 1 shared Elizabeth M. McNair· 1 shared Erica Fennimore· 1 shared Ethan PaulаkonisiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Adeleye James AfolayanORCID

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2 papers

Recent·Most cited

NeuroscienceAlzheimer s & DementiaPeer-reviewedJul 1, 2025

Loss of neuronal lysosomal acid lipase drives amyloid pathology in Alzheimer's disease

Alexandra Barnett, Elizabeth M. McNair, Lamar Dawkins…·Leon G. Coleman

This study identifies neuronal lysosomal acid lipase (LAL) loss as a driver of amyloid pathology in Alzheimer's disease by linking disrupted lipophagy to Aβ accumulation and cognitive deficits.

11 citationstop 2%

humanmouse

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BiochemistrybioRxivPreprintFeb 17, 2025

Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering

Mariah S. Stewart, Chathura Paththamperuma, Colleen M. McCann…·Jonathan Cummings Schisler

This study examines how phosphorylation at HSP70 T636 affects its binding to CHIP, showing reduced affinity and altered interactions with other co-chaperones, with implications for disease.

1 citation

protein structureexperimental assay

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