Anti-malaria RTS,S/AS01 vaccine generates a limited pool of memory B cells expressing specificities associated with protection
Jason Netland, Christopher D. Thouvenel, Scott Gregory, William C. T. Adams, Erik Jongert, Natalie Brunette, Neil P. King, Neville K. Kisalu, C. Richter King, David J. Rawlings, Marion Pepper
The paper examines how RTS,S/AS01 vaccine induces transient protective B cell responses against malaria, which are later replaced by non-protective memory B cells, explaining its limited long-term efficacy.
bioRxiv · Aug 18, 2026 · PreprintImmunology