Marion Pepper

Maternal microchimerism in Malian cord blood is associated with fewer Pf-responsive ZBTB16+ CD4 and Vγ9Vδ2 T cells, and with infant malaria outcomes.

A prime-editing recorder in one mouse embryo yields a dated, zygote-rooted lineage tree of 1.28M cells at E13.5, enabling clonal dominance, sibling-fate and cell-type coupling analyses.

This study shows that lymphatic networks create spatially distinct environments in draining lymph nodes that influence B cell differentiation, affinity selection, and antibody isotype, which can be manipulated through vaccine design.

The paper profiles mouse CD4+ T cells across >700 samples to identify 20 molecular states, revealing diverse effector functions and unexpected similarities between Tfh and chronically stimulated states.

The paper shows that the repetitive structure of the Plasmodium CSP protein affects B cell memory, leading to reduced humoral immunity over time.

The paper examines how RTS,S/AS01 vaccine induces transient protective B cell responses against malaria, which are later replaced by non-protective memory B cells, explaining its limited long-term efficacy.

This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.

The paper identifies BCL6 and CD4+ T cell dependence in generating functional IgM+ memory B cells independent of germinal center formation.

This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.