A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics
Georges A. Leconte, Gillian E. Gadbois, Yadira J Sepulveda, Ady Schwarz, Erin Chang, Raymond T. Suhandynata, Jeremiah D. Momper, Fleur M. Ferguson
This study identifies fatty acid promoieties that improve CNS exposure of targeted protein degraders by enhancing pharmacokinetics and BBB permeability.
Journal of Medicinal Chemistry · Aug 5, 2025Peer-reviewedPharmacology & Toxicology