Fleur M. Ferguson

This paper introduces a degron decoy system that uses pathological seeding to clear multimeric α-synuclein by co-aggregating with oligomers and enabling degradation via a small molecule trigger.

TubercuProbe prioritizes compound-protein interactions in Mycobacterium tuberculosis using a cross-attention graph-sequence model trained on human chemoproteomic data.

This paper develops PROTACs to degrade oncogenic TRK fusions, showing improved efficacy compared to traditional inhibitors.

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

This study identifies fatty acid promoieties that improve CNS exposure of targeted protein degraders by enhancing pharmacokinetics and BBB permeability.

This study develops a kinetic scout approach to accelerate targeted protein degrader development by tuning ligand residence time through chemical proteomics and mechanistic assays.