Molecular basis of proton-sensing by G protein-coupled receptors
Matthew K. Howard, Nicholas Hoppe, Xi-Ping Huang, Darko Mitrovic, Christian B. Billesbølle, Christian B. Macdonald, Eshan Mehrotra, Patrick Rockefeller Grimes, Donovan D. Trinidad, Lucie Delemotte, Justin G. English, Willow Coyote-Maestas, Aashish Manglik
The paper identifies proton-sensing mechanisms in GPCRs using cryo-EM and deep mutational scanning, revealing a network of residues rather than a single site for proton recognition.
bioRxiv · Apr 17, 2024Biochemistry