Author
University of California, San FranciscoORCID 0000-0002-5946-2926Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Marybeth Howard, Eve J. Fine, Karthik Srinivasan…·Willow Coyote‐Maestas
This study uses deep mutational pharmacology to show how different residues in the -opioid receptor determine the efficacy of opioids by shaping distinct activation mechanisms.
Matthew K. Howard, Nicholas Hoppe, Xi‐Ping Huang…·Aashish Manglik
The paper identifies proton-sensing mechanisms in GPCRs using cryo-EM and deep mutational scanning, revealing a network of residues rather than a single site for proton recognition.
Christian B. Macdonald, David M. Nedrud, Patrick Rockefeller Grimes…·Willow Coyote‐Maestas
The paper introduces DIMPLE, a method for generating indel and missense mutation libraries, and demonstrates its application in studying the impact of mutations on protein function.