Author

Darko Mitrovic

Science for Life LaboratoryORCID 0000-0002-3219-1062Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Lucie DelemotteiD· 2 shared Aashish ManglikiD· 1 shared Antoni MarciniakiD· 1 shared Christian B. BillesbølleiD· 1 shared Christian B. MacdonaldiD· 1 shared Donovan D. TrinidadiD· 1 shared Eshan MehrotraiD· 1 shared Justin G. EnglishiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

Lucie DelemotteORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJun 30, 2026

Who's driving? Common evolutionary mechanism of activation of class A GPCRs

Antoni Marciniak, Paweł Kozielewicz, Darko Mitrovic, Lucie Delemotte

The paper identifies a common evolutionary mechanism for class A GPCR activation using coevolution and machine learning, validated through molecular dynamics simulations and ligand effect modeling.

DOI 10.64898/2026.06.25.734477

machine learning (classical)

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BiochemistryCellPeer-reviewedJan 2, 2025

Molecular basis of proton-sensing by G protein-coupled receptors

Matthew K. Howard, Nicholas Hoppe, Xi‐Ping Huang…·Aashish Manglik

The paper identifies proton-sensing mechanisms in GPCRs using cryo-EM and deep mutational scanning, revealing a network of residues rather than a single site for proton recognition.

84 citationstop 1%

humanstructural biology

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